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1999

Auto-inactivation by Cleavage within the Dimer Interface of Kaposi's Sarcoma-associated Herpesvirus Protease. T.R. Pray, A.M. Nomura, M.W. Pennington & C.S. Craik. J. Mol. Bio. 289, 197-203 (1999)

Reverse Biochemistry: Use of Macromolecular Protease Inhibitors To Dissect Complex Biological Processes and Identify a Membrane-Type Serine Protease in Epithelial Cancer and Normal Tissue. T. Takeuchi, M.A. Shuman & C.S. Craik. Proc. Natl. Acad. Sci 96, 11054-11061 (1999)

1998

Domain Flexibility in Retroviral Proteases: Structural Implications for Drug Resistant Mutations. R.B. Rosé, C.S. Craik & R.M. Stroud. Biochem. 37 (8), 2601-2621 (1998)

Determining Protein-Protein Interactions by Oxidative Crosslinking of a GGH-Fusion Protein. K.C. Brown, Z. Yu, A.L. Burlingame & C.S. Craik. Biochem. 37 (13), 4397-4406 (1998)

Ecotin: A Serine Protease Inhibitor with Two Distinct and Interacting Binding Sites. Q. Yang, C.-I. Wang, S.A. Gillmor, R. J. Fletterick & C.S. Craik. J. Mol. Bio. 279 (4), 945-957 (1998)

Engineering Bidentate Macromolecular Inhibitors for Trypsin and Urokinase-type Plasminogen Activator. Q. Yang & C.S. Craik. J. Mol. Bio. 279 (4), 1001-1011 (1998)

Engineering Enzyme Specificity. J.L. Harris & C.S. Craik. Curr. Opin. Chem Bio. 2 (1), 127-132 (1998)

Engineering Catalytically Defective Forms of HIV Protease to Modulate Its Activity. C.S. Craik, L.M. Babé, D.S. Dauber, F. McPhee, J. Rosé & A. Ünal. Adv. Exptl. Med. Bio. 436, 436-431 (1998)

Optimization of a Macromolecular Inhibitor of HIV-1 Protease. D.S. Dauber, F. McPhee, A. Ünal & C.S. Craik. Adv. Exptl. Med. Bio. 436, 65-70 (1998)

Definition and Redesign of the Extended Substrate Specificity of Granzyme B. J.L. Harris, E.P. Peterson, D. Hudig, N.A. Thornberry & C.S. Craik. J. Bio. Chem. 273, 27364-27373 (1998)

1997

Crystal Structure of an Ecotin-Collegenase Complex Suggests a Model for Recognition and Cleavage of the Collagen Triple Helix. J.J. Perona, C.A. Tsu, C.S. Craik & R.J. Fletterick. Biochem. 36, 5381-5392 (1997)

Structural Basis for the Broad Substrate Specificity of Fiddler Crab Collagenolytic Serine Protease 1. C.S. Tsu, J.J. Perona, R.J. Fletterick & C.S. Craik. Biochem. 36, 5393-5401 (1997)

Obstruction of HIV-1 Particle Release by Interferon-a Occurs Before Viral Protease Processing and is Independent of Envelope Glycoprotein. L.M. Babé, A. Ünal, & C.S. Craik. J. Interferon and Cytokine Res. 17, 287-293 (1997)

Use of the Intestinal Bile Acid Transporter for the Uptake of Cholic Acid Conjugates with HIV-1 Protease Inhibitor Activity. M. Kagedahl, P.W. Swaan, C.T. Redemann, M. Tang, C.S. Craik, F.C. Szoka & S. Oie.Pharmaceuticals. Res. 14, 176-180 (1997)

P-4 and RNKP-7, New Granzyme-like Serine Proteases Expressed in Activated Rat Lymphocytes. G.R. Ewoldt, M.J. Smyth, P.K. Darcy, J.L Harris, D. Hudig & C.S. Craik. J. Immunology 158, 4574-4583 (1997)

The Protease and Assembly Protein of Kaposi's Sarcoma-Associated Herpesvirus (Human Herpesvirus 8). A. Ünal, T.R. Pray, M. Lahunoff, M.W. Pennington, D. Ganem & C.S. Craik. J. Virol. 71, 7030-7038 (1997)

Structural Determinants of Specificity in the Cysteine Protease Cruzain. S.A. Gillmor, C.S. Craik & R.J. Fletterick. Protein Sci. 6, 1603-1611 (1997)

The Discovery, Characterization and Crystallographically Determined Binding Mode of a FMOC-Containing Inhibitor of HIV-1 Protease. E.E. Rutenber, J.J. DeVoss, L. Hoffman, R.M. Stroud, K.H. Lee, J. Alvarez, F. McPhee, C. Craik & P.R. Ortiz de Montellano. Bioorg. & Med. Chem. Ltrs. 5, 1311-1320 (1997)

Viral Proteases: Evolution of Diverse Structural Motifs to Optimize Function. L.M. Babé & C.S. Craik. Cell 91, 427-430 (1997)

Alkylation of a Catalytic Aspartate Group of the SIV Protease by an Epoxide Inhibitor. P.S. Caldera, Z. Yu, R.M.A. Knegtel, F. McPhee, A.L. Burlingame, C.S. Craik, I.D. Kuntz & P. Ortiz de Montellano. Bioorg. & Med. Chem. 5, 2019-2027 (1997)

The Marriage of Protein Structure and Pharmaceutical Discovery. C.S. Craik & R.J. Fletterick. Biotech. & Appl. Biochem. 26, 125-126 (1997)

Evolutionary Divergence of Substrate Specificity Within the Chymotrypsin-like Serine Protease Fold. J. Perona & C.S. Craik. J. Biological Chemistry 272, 29987-29990 (1997)

1996

Regulation of Proteolytic Activity by Engineered Tridentate Metal Binding Loops. S. Halfon & C.S. Craik. J. Am. Chem. Soc. 118, 1227-1228 (1996)

Isolation and Characterization of Two cDNAs from Atlantic Cod Encoding Two Distinct Psychrophilic Elastases. E. Gudmundsdottir, R. Spilliaert, Q. Yang, C.S. Craik, J.D. Bjarnason & A. Gudmundsottir. Comparative Biochem. and Physiology Part B Biochem. & Molecular Biology 113, 795-801 (1996)

Delocalizing Trypsin Specificity with Metal-Activation. W.S. Willett, L.S. Brinen, R.J. Fletterick & C.S. Craik. Biochem. 35, 5992-5998(1996)

X-ray Structures of a Designed Binding Site in Trypsin Show Metal-Dependent Geometry. L.S. Brinen, W.S. Willett, C.S. Craik, & R.J. Fletterick. Biochem. 35, 5999-6009 (1996)

Substrate Recognition by Recombinant Serine Collagenase 1 from Uca pugilator. C.S. Tsu & C.S. Craik. J. Bio. Chem. 279, 11563-11570 (1996)

Irreversible Inhibition of the HIV-1 Protease: Targeting Alkylating Agents to the Catalytic Aspartate Groups. Z. Yu, P. Caldera, F. McPhee, J. DeVoss, P.R. Jones, A. Burlingame, I. Kuntz, C.S. Craik & P.R. Ortiz de Montellano. J. Amer. Chem. Soc. 118, 5846-5856 (1996)

Structure-based Design of Parasitic Protease Inhibitors. R. Li, X. Chen, B. Gong, Z. Li, E. Davidson, G. Kurzban, R.E. Miller, E.O. Nuzman, J.H. McKerrow, R.J. Fletterick, S.A. Gillmore, C.S. Craik, I.D. Kuntz, F.E. Cohen & G.L. Kenyon. Bioorg. & Med. Chem. 4, 1421-1427 (1996)

A New Class of HIV1 Protease Inhibitor: The Crystallographic Structure, Inhibition and Chemical Synthesis of an Aminimide Peptide Isostere. E.E. Rutenber, F. McPhee, A.P. Kaplan, S.L. Gallion, J.C. Hogan Jr., C.S. Craik & R.M. Stroud. Bioorg.& Med. Chem. 4,1545-1558 (1996)

Bile Pigments as HIV-1 Protease Inhibitors and their Effects on HIV-1 Viral Maturation and Infectivity In Vitro. F. McPhee, P. Caldera, G. Bemis, A. McDonagh, I.D. Kuntz & C.S. Craik. Biochem. J. 320, 681-686 (1996)

Engineering Human Immunodeficiency Virus 1 Protease Heterodimers as Macromolecular Inhibitors of Viral Maturation. F. McPhee, A.C. Good, I.D. Kuntz & C.S. Craik. Proc. Natl. Acad. Sci. 93, 11477-11481 (1996)

Intracellular Expression of HIV-1 Protease Inhibitor Resistant HIV-1 Strains in Human T Cell Lines. U. Junker, S. Escaich, I. Plavec, J. Baker, F. McPhee, J.R Ros é, C.S. Craik & E. Böhnlein. J. Virol. 70, 7765-7772 1996)

Three-Dimensional Structures of HIV-1 Protease Product Complexes. R.B. Rosè, C.S. Craik, N.L. Douglas & R.M. Stroud. Biochem J. 35, 12933-12944 (1996)

Phage Display of Proteases and Macromolecular Inhibitors. C.I. Wang, Q. Yang, & C.S. Craik. Methods in Enzymology. Edited by: J.N. Abelson, Academic Press, Orlando, FL. 267,52-68 (1996)

1995

Engineered Metal Regulation of Trypsin Specificity. W.S. Willett, S. Gillmore, J.J. Perona, R.J. Fletterick & C.S. Craik. Biochem. 34, 2172-2180 (1995)

Defining the Level of HIV-1 Protease Activity Required for HIV-1 Particle Maturation and Infectivity. J.R. Rosé, L. Babé & C.S. Craik. J. Virol. 69, 2751-2758(1995)

The Crystal Structure of Cruzain: A Therapeutic Target for Chagas' Disease. M.E. McGrath, A.E. Eakin, J.C. Engel, J.H. McKerrow, C.S. Craik & R.J. Fletterick. J. Mol. Bio. 247, 251-259 (1995)

Isolation of a High Affinity Inhibitor of Urokinase-Type Plasminogen Activator by Phage Display of Ecotin. C.-I. Wang, Q. Yang & C.S. Craik. J. Bio. Chem. 270, 12250-12256 (1995)

Conversion of Human 15-Lipoxygenase to an Efficient 12-Lipoxygenase: The Side Chain Geometry of Amino Acids 417 and 418 Determine Positional Specificity. D.L. Sloane, R. Leung, J. Barnett, C.S. Craik & E. Sigal.Protein Engineering 8, 275-282 (1995)

Trypsin Specificity Increased Through Substrate-Assisted Catalysis. D.R. Corey, W.S. Willet, G.S. Coombs & C.S. Craik. Biochem. 34, 11521-11527 (1995)

Trans-Dominant Inhibitory Human Immunodeficiency Virus Type 1 Protease Monomers Prevent Protease Activation and Virion Maturation. L.M. Babé J. Rosé & C.S. Craik. Proc. Natl. Acad. Sci. USA 92, 10069-10073 (1995)

Regulation of Clathrin Assembly and Trimerization Defined Using Recombinant Triskelion Hubs. S.-H. Liu, M.L. Wong, C.S. Craik & F. Brodsky. Cell 83, 257-267 (1995)

A Cysteine Protease is a Target for the Enzyme Structure-based Design of Antiparasitic Drugs. A.E. Eakin, J.H. McKerrow & C.S.Craik. Drug Information Journal 29, 1501S-1517S (1995)

Structural Basis of Substrate Specificity in the Serine Proteases. J.J. Perona & C.S. Craik. Protein Science 4, 337-360 (1995)

1994

Exogenous Acetate Reconstitutes the Enzymatic Activity of Trypsin Asp189Ser. J. Perona, L. Hedstrom, R. Wagner, W. Rutter, C.S. Craik & R.J. Fletterick. Biochem. 33, 3252-3259 (1994)

Haloperidol-Based Irreversible Inhibitors of the HIV-1 and HIV-2 Proteases. J.J. DeVoss, Z. Sui, D.L. DeCamp, R. Salto, L.M. Babé, C.S. Craik & P. Ortiz de Montellano. J. of Med. Chem. 37, 665-673 (1994)

In Vitro Characterization of Nonpeptide Irreversible Inhibitors of HIV Proteases. R. Salto, L.M. Babé, J. Li, J.R. Rosé, Z. Yu, A Burlingame, J. J. DeVoss, Z. Sui, P. Ortiz de Montellano & C.S. Craik. J. Bio. Chem. 269, 10691-10698 (1994)

The Substrate Specificity of Uca Pugilator Collagenolytic Serine Protease 1 Correlates with the Bovine Type I Collagen Cleavage Sites. C.A. Tsu, J.J. Perona, V. Schellenberger, C.W. Turck & C.S. Craik. J. Bio. Chem.269, 19565-19572 (1994)

Can Small Cyclic Peptides Have the Activity and Specificity of Proteolytic Enzymes? B.W. Matthews, C.S.Craik & H. Neurath. Proc. Natl. Acad. Sci. USA 91, 4103-4105 (1994)

Constitutive Production of Non-Enveloped HIV-1 Particles by a Mammalian Cell Line and the Effects of a Protease Inhibitor on Particle Maturation. L.M. Babé & C.S. Craik. Antimicrobial Agents and Chemo. 38, 2430-2439 (1994)

Atlantic Cod cDNA Encoding a Psychrophilic Chymotrypsinogen. A. Guomundsdóttir, S. Óskarsson, A.E. Eakin, C.S. Craik & J.B. Bjarnason. Biochimica et Biophysica Acta 1219, 211-214 (1994)

Structure Assisted Design of Nonpeptide HIV-1 Protease Inhibitors. J.R. Rosé & C.S. Craik. American Journal of Respiratory and Critical Care Medicine 150, S176-S182 (1994)

Nonpeptide HIV Protease Inhibitors. Differential Introduction of Alkylamino Groups into the two Aryl Rings of Haloperidol. K.L. Lee, F. McPhee, J.J. DeVoss, C.S. Craik & P. Ortiz de Montellano. J. of Organic Chemistry 59, 6194-6199 (1994)

1993

Regulation of Autoproteolysis of the HIV-1 and HIV-2 Proteases with Engineered Amino Acid Substitutions. J.R. Rosé, R. Salto & C.S. Craik. J. Bio. Chem. 268, 11939-11945 (1993)

Boronated Porphyrins—A New Class of HIV Proteinase Inhibitors. D.L. Decamp, S.B. Kahl & C.S. Craik. Intl. Antiviral News 1, 19-20 (1993)

Production of Crystallizable Cruzain, the Major Cysteine Protease from Trypanosoma cruzi. A.E. Eakin, M.E. McGrath, J.H. McKerrow, R. J. Fletterick & C.S. Craik. J. Bio. Chem. 268, 6115-6118 (1993)

Crystal Structures of Rat Anionic Trypsin Complexed with the Protein Inhibitors APPI and BPTI. J.J. Perona, C.A. Tsu,C.S. Craik & R.J. Fletterick. J. Mol. Bio. 230, 919-933 (1993)

Structure of an Engineered, Metal-Actuated Switch in Trypsin. M.E. McGrath, B.L. Haymore, N.L. Summers, C.S. Craik & R. J. Fletterick. Biochem. 32, 1914-1919 (1993)

Trypsin Display on the Surface of Bacteriophage. D.R. Corey, A.K. Shiau, Q. Yang, B.A. Janowski & C.S. Craik. Gene 128, 129-134 (1993)

Peptidomimetic Inibitors of Human Immunodeficiency Virus Protease (HIV-PR): Design, Enzyme Binding and Selectivity, Antiviral Efficacy and Cell Permeability Properties. T.K. Sawyer, J.F. Fisher, J.B. Hester, C.W. Smith, A.G. Tomasselli, W.G. Tarpley, P.S. Burton, J.O. Hui T.J. McQuade, R.A. Conradi, V.S. Bradford, L. Liu, J.H. Kinner, J.Tustin,D.L. Alexander, A.W. Harrison, D.E. Emmert, D.J. Staples, L.I. Maggira, Y.Z. Zhang, R.A. Poorman, BM. Dunn, C. Rao, .E. Scarborough, W.T. Lowther, C.S. Craik, D. DeCamp, J.Moon, W.H. Howe & R.L. Heinrikson. Bioorg. Med. Chem. Letts 3, 819-824 (1993)

Structure of a Non-Peptide Inhibitor Complexed with HIV-1 Protease: Developing a Cycle of Structure-Based Drug Design. E. Rutenber, E.B. Fauman, R.J. Keenan, S. Fong, P.S. Furth, P.R. Ortiz de Montellano, E. Meng, I.D. Kuntz, D.L. DeCamp, R. Salto, J.R. Rosé, C.S. Craik, R.M. Stroud. J. Bio. Chem. 268, 15343-15346 (1993)

Relocating a Negative Charge in the Binding Pocket of Trypsin. J.J. Perona, C.A. Tsu, M.E. McGrath, C.S. Craik & R.J. Fletterick. J. Mol. Bio. 230, 934-949 (1993)

Isolation and Characterization of cDNAs from Atlantic Cod Encoding Two Different Forms of Trypsinogen. A. Gudmundsdottir, E. Gudmundsdottir, S. Oskarsson, J.B. Bjarnason, A.E. Eakin & C. S. Craik. European J. Biochem. 217, 1091-1097 (1993)

Locating the Catalytic Water in Serine Proteases. J.J. Perona, C.S. Craik & R.J. Fletterick. Science 261, 620-621 (1993)

Structure of the Protease from Simian Immunodeficiency Virus: Complex with an Irreversible Nonpeptide Inhibitor. B. Rose, J.R. Rosé, R. Salto, C.S. Craik & R. Stroud. Biochem. 32, 12498-12507 (1993)

A Genetic Selection Elucidates Structural Determinants of Arginine Versus Lysine Specificity in Trypsin. J.J. Perona, L.B. Evnin & C.S, Craik. Gene 137, 121-126 (1993)

Synthesis of Haloperidol Ethanedithioketal HIV-1 Protease Inhibitors: Magnesium Chloride Facilitated Addition of Grignard Reagents. Z. Sui, J. DeVoss, D. DeCamp, J. Li, C.S. Craik & P.R. Ortiz de Montellano.Synthesis 8, 803-808 (1993)

Inhibition of the HIV1 and the HIV2 Proteases by Curcumin and Curcumin Boron Complexes. Z. Sui, R. Salto, C.S. Craik, P. Ortiz de Montellano. Bioorg. & Med. Chem. Let. 1, 415-422 (1993)

1992

An Investigation Into the Minimum Requirements for Peptide Hydrolysis by Mutation of the Catalytic Triad of Trypsin. D.R. Corey & C.S. Craik. J. Am. ChemSoc. 114, 1784-1790 (1992)

The Sequence, Organization and Expression of the Major Cysteine Protease (Cruzain) from Trypanosoma cruzi. A.E. Eakin, A.A. Mills, G. Harth, J.H. McKerrow & C.S. Craik. J. Bio. Chem. 267, 7411-7420 (1992)

Engineered Metalloregulation in Enzymes. J. Higaki, R.J. Fletterick & C.S. Craik. Trends in Bio. Sci. 17, 100-104 (1992)

An Alternate Geometry for the Catalytic Triad of Serine Proteases. D.R. Corey, M.E. McGrath, J.R. Vasquez, R.J. Fletterick & C.S. Craik. J. Amer. Chem. Soc. 114, 4906-4907 (1992)

Synthetic “Interface” Peptides Alter Dimeric Assembly of the HIV-1 and -2 Proteases. L.M. Babé, J. Rosé & C.S. Craik. Protein Sci. 1,1244-1253 (1992)

Perturbing the Polar Environment of Asp102 in Trypsin: Consequences of Replacing Conserved Ser214. M.E. McGrath, J.R. Vasquez, C.S. Craik, A.S. Yang, B. Honig & R.J. Fletterick. Biochem. 31, 3059-3064 (1992)

HIV Protease (HIV PR) Inhibitor Structure-Activity-Selectivity and Active Site Molecular Modeling of High Affinity Leu [CH(OH)CH2]Val Modified Viral and Nonviral Substrate Analogs. T.K. Sawyer, D.J. Staples, L. Liu, A.G. Tomasselli, J.O. Hui, K. O'Connell,H. Schostarez, J.B. Hester, J. Moon, W.J. Howe, C.W. Smith, D. L. DeCamp, C.S. Craik, B.M. Dunn,W. T. Lowther, J. Harris, R.A. Poorman, A. Wlodawer, M. Jaskolski & R.L. Heinrikson. Int. J. Pep. Protein Res. 40, 274-281 (1992)

Specific Inhibition of HIV-1 Protease by Boronated Porphyrins. D. L. DeCamp, L.M. Babé, R. Salto, J.L. Lucich, M.-S. Koo, S.B. Kahl & C.S. Craik. J. Med. Chem. 35, 3426-3428

Location of the New Escherichia coli Gene eco, Encoding the Serine Protease Inhibitor Ecotin. T. Erpel, P. Hwang, C.S. Craik, R.J. Fletterick, M. McGrath. J. of Bacteriology 174, 1704 (1992)

1991

Inhibition of HIV Protease Activity by Heterodimer Formation. L.M. Babé, S. Pichuantes & C.S. Craik. Biochem. 30, 107-111 (1991)

The Sequence and Reactive Site of Ecotin: A General Inhibitor of Pancreatic Serine Proteases from E. coli. M.E. McGrath, W.M. Hines, J.A. Sakanari, R.J. Fletterick & C.S. Craik. J. Bio. Chem. 266, 6620-6625 (1991)

Calcium-Free Calmodulin Is a Substrate of Proteases From Human Immunodeficiency Viruses 1 and 2. A.G. Tomasselli, W.J. Howe, J.O. Hui, T.K. Sawyer, I.M. Reardon, D.L. DeCamp, C.S. Craik & R.L. Heinrikson.Proteins: Str., Funct. & Gen. 10, 1-9 (1991)

Crystallographic Analysis of Trypsin G226A: A Specificity Pocket Mutant of Rat Trypsin with Altered Binding and Catalysis. M. Wilke, J. Higaki, C.S. Craik & R.J. Fletterick. J. Mol. Bio. 219, 525-532 (1991)

Crystal Structure of Rat Trypsin-S195C at -150°C. Analysis of Low Activity of Recombinant and Semi-Synthetic Thiol Proteases. M. Wilke, J. Higaki, C.S. Craik & R.J. Fletterick. J. Mol Bio. 219, 511-523 (1991)

Modus Operandi. C.S.Craik. Nature 353, 469 (1991)

Å Structure of Trypsin at 120°K: Comparison of Low Temperature and Room Temperature Structures. T. Earnest, E. Fauman, C.S. Craik & R. Stroud. Proteins: Str., Funct. & Gen. 10, 171-187 (1991)

A Primary Determinant for Lipoxygenase Postional Specificity. D.L. Sloane, R. Leung, C.S. Craik & E. Sigal. Nature 354, 149-152 (1991)

Structure-based inhibition of HIV-1 protease activity and viral infectivity. D.L. DeCamp, L.M. Babé, P. Furth, P. Ortiz de Montellano, I.D. Kuntz & C.S. Craik. Adv. Exptl. Med. Bio. 306, 489-492 (1991)

1990

Amplification and Sequencing of Genomic DNA Fragments Encoding Cysteine Proteases from Protozoan Parasites. A.E. Eakin, J. Bouvier, J.A. Sakanari, C.S. Craik & J.H. McKerrow. Mol. Biochem. Parasitol. 39, 1-8 (1990)

Immunologic and Proteolytic Analysis of HIV-2 Reverse Transcriptase Structure. A.L. Ferris, A. Hizi, S.D. Showalter, S. Pichuantes, L. Babé & C.S. Craik. Virology 175, 456-464 (1990)

Expression of Cloned Human Reticulocyte 15-Lipoxygenase and Immunological Evidence that 15-Lipoxygenase of Different Cell Types Are Related. E. Sigal, D. Grunberger, E. Highland, C. Gross, R.A.F. Dixon & C.S. Craik. J. Bio. Chem. 265, 5113-5120 (1990)

Recombinant HIV 2 Protease Processes HIV 1 Pr53gag and Analogous Junction Peptides In Vitro. S. Pichuantes, L. Babé, P. Barr, D. DeCamp & C.S. Craik. J. Bio. Chem. 265, 13890-13898 (1990)

Specificity and Inhibition of Proteases from Human Immunodeficiency Viruses 1 and 2. A. Tomasselli J. Hui, T. Sawyer, D. Staples, C. Bannow, I. Reardon, W. Howe, D. DeCamp, C.S. Craik & R. Heinrikson. J. Bio. Chem. 265, 14675-14683 (1990)

Regulation of Serine Protease Activity by an Engineered Metal Switch. J.N. Higaki, B.L. Haymore, S. Chen, R.J. Fletterick & C.S. Craik. Biochem. 29, 8582-8586 (1990)

Homeodomain of Yeast Repressor a2 Contains Nuclear Localization Signal. M. Hall, C.S. Craik & Y. Hiraoko. Proc. Natl. Acad. Sci. USA 87, 6954-6958 (1990)

Structure-Based Design of Nonpeptide Inhibitors Specific for the Human Immunodeficiency Virus 1 Protease. R.L. DesJarlais, G.L. Seibel, I.D. Kuntz, P.S. Furth, J.C. Alvarez, P.R. Ortiz de Montellano, D.L. DeCamp, L.M. Babé & C.S. Craik. ProcNatl. Acad. Sci. USA 87, 6644-6648 (1990)

Characterization of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Enzyme Produced in Yeast. I.C. Bathurst, L.K. Moen, M.A. Lujan, H.L. Gibson, P.H. Feucht, S. Pichuantes, C.S. Craik, D.V. Santi & P.J. Barr. Biochem. Biophys. Res. Commun. 171, 589-595 (1990)

Substrate Specificity of Trypsin Investigated Using a Genetic Selection. L. Evnin, J. Vasquez & C.S. Craik. Proc. Natl. Acad. Sci. USA 87, 6659-6663 (1990)

Human Mast Cell Tryptase: Multiple cDNAs and Genes Reveal a Multigene Serine Protease Family. P. Vanderslice, S.M. Ballinger, E.K. Tam, S.M. Goldstein, C.S. Craik & G.H. Caughey. Proc. Natl. Acad. Sci. USA87, 3811-3815 (1990)

Secretion of Active Kringle 2-Serine Protease in E. coli. M. Obukowicz, M. Gustafson, K. Junger, R. Leimgruber, A. Wittwer, T-C. Wun, T. Warren, B. Bishop, K. Mathis, D. McPherson, N. Siegel, M. Jennings, B. Brightwell, J. Diaz-Collier, L. Bell, C.S. Craik & W. Tacon. J. Bio. Chem. 29, 9737-9745 (1990)

Human CPA Identifies a BglII RFLP and Maps to 7q31-qter. E. Stewart, C.S. Craik, L. Hake & A. Bowcock. Amer. J. Hum. Gen. 46, 795 -800 (1990)

The Expression of Active Human Reticulocyte 15-Lipoxygenase in Bacteria. D.L. Sloane, C.S. Craik & E. Sigal. Biomed. Biochem. Acta 49, 511-516 (1990)