Home Screen Our Work Who we are Publications Fun stuff
Publications
 

1989

An Expression System for Trypsin. J. Vasquez, L. Evnin, J. Higaki & C.S. Craik. J.  Cell. Biochem. 39, 265-267 (1989)

Rapid Preparation of Proteins for Crystallization Trials. M. McGrath, R.J. Fletterick & C.S. Craik. Biotechniques 7, 246-247 (1989)

Molecular Cloning of Dog Mast Cell Tryptase and a Related Protease: Structural Evidence of a Unique Mode of Serine Protease Activation. P. Vanderslice, C.S. Craik, J.A. Nadel & G.H. Caughey. Biochem. 28, 4148-4155 (1989)

Serine Proteases from Nematode and Protozoan Parasites: Isolation of Sequence Homologues Using Generic Molecular Probes. J. Sakanari, C.E. Staunton, A.E. Eakin, C.S. Craik & J.H. McKerrow. Proc. Natl. Acad. Sci. USA 86, 4863-4867 (1989)

Introduction of a Cysteine Protease Active Site into Trypsin. J. Higaki L.B. Evnin & C.S. Craik. Biochem. 28, 9256-9263 (1989)

Crystal Structures of Two Engineered Thiol Trypsins. M. McGrath, M.E. Wilke, J.N. Higaki, C.S. Craik & R.J. Fletterick. Biochem. 28, 9264-9270 (1989)

Cysteine or Serine Proteinase. A. Eakin, J.N. Higaki, J.H. McKerrow & C.S. Craik. Nature 342, 132 (1989)

Recombinant HIV-1 Protease Secreted by Saccharomyces cerevisiae Correctly Processes  Myristylated gag Polyprotein. S. Pichuantes, L. Babé, P. Barr & C.S. Craik.  Proteins: Str., Funct. & Gen. 6, 324-337 (1989)

1988

Arachidonate 15-Lipoxygenase from Human Eosinophil-Enriched Leukocytes: Partial Purification and Properties. E. Sigal, D. Grunberger, J.R. Cashman, C.S. Craik, G.H. Caughey & J.A. Nadel. Biochem. Biophys. Res. Comm. 150, 376-383 (1988)

Arachidonate 15-Lipoxygenase from Human Leucocytes: Purification and Structural Homology to Other Mammalian Lipoxygenases. E. Sigal, D. Grunberger, J.R. Cashman,  C.S. Craik, G.H. Caughey & J.A. Nadel. J. Bio. Chem. 263, 5328-5332 (1988)

A Novel Rat Carboxypeptidase, CPA2: Characterization, Molecular Cloning, and Evolutionary Implications on Substrate Specificity in the Carboxypeptidase Gene Family. S.J. Gardell, C.S. Craik, E. Clauser, E. Goldsmith, C.B. Stewart, M. Graf & W.J. Rutter. J. Bio. Chem. 263, 17828-17836 (1988)

Structural Characterization of the Rat Carboxypeptidase Gene Family. E. Clauser, S. Gardell C.S. Craik, R.J. MacDonald & W.J. Rutter. J. Bio. Chem. 263,17837-17845 (1988)

Efficient Targeting to Storage Granules of Human Proinsulin Lacking an Intact Propeptide Domain. S.K. Powell, L. Orci, C.S. Craik & H-P. Moore. J. Cell Bio. 106, 1834-1851 (1988)

Development of an Efficient Method for Generating and Screening Active Trypsins and Variants.  L. Evnin & C.S. Craik. Ann. N. Y. Acad. Sci. 542, 61-74 (1988)

Molecular Cloning and Primary Structure of Human 15-Lipoxygenase. E. Sigal, C.S. Craik, E. Highland, D. Grunberger, L. Costello, R. Dixon & J. Nadel. Biochem. Biophys. Res. Comm. 157, 457-464 (1988)

Structural and Functional Integrity of Specificity and Catalytic Sites of Trypsin. L. Graf, G. Hegyi, I. Liko, J. Hepp, K. Medzihradsky, C.S. Craik & W.J. Rutter.  Intl. J. Pep. Prot. Res. 32, 512-518 (1988)

1987

Redesigning Trypsin via Genetic Engineering. C.S. Craik, S. Roczniak, S. Sprang, R.J. Fletterick & W. J Rutter. J. Cell. Biochem. 33, 199-211 (1987)

Redesigning Trypsin via Genetic Engineering. C.S. Craik, S. Roczniak, S. Sprang, R.J. Fletterick & W.J. Rutter. In: Proteases in Biological Control and Biotechnology, pp. 183-195. Edited by D. Cunningham and G. Long. New York: Alan R Liss, Inc. (1987)

Redesigning Proteins via Genetic Engineering. W.J. Rutter, S.J. Gardell, S. Roczniak, D. Hilvert, S. Sprang, R.J. Fletterick & C.S. Craik.  In: Protein Modification and Design, pp. 257-267. Edited by D. Oxender and C.F. Fox. New York: Alan R. Liss, Inc. (1987)

Replacement of Lysine Residue 1030 in the Putative ATP-Binding Region of the Insulin; Receptor Abolishes Insulin and Antibody Stimulated Glucose Uptake and Receptor Kinase Activity. Y. Ebina, E. Araki, M. Taira, P. Shimada, M. Mori, C.S. Craik, K. Siddle, S. Pierce, R. Roth & W. Rutter. Proc. Natl. Acad. Sci. USA 84, 704-708 (1987)

Selective Alteration of Substrate Specificity by Replacement of Aspartic Acid-189 with Lysine in the Binding Pocket of Trypsin. L. Graf, C.S. Craik, A. Patthy, S. Roczniak, R.J. Fletterick & W.J. Rutter. Biochem. 26, 2616-2623 (1987)

The Catalytic Role of the Active Site Aspartic Acid in Serine Proteases. C.S. Craik, S. Roczniak, C. Largman & W.J. Rutter. Science 237, 909-913 (1987)

The Three Dimensional Structure of Asnl02 Trypsin: Role of Aspl02 in Serine Protease Catalysis. S. Sprang, T. Standing, R.J. Fletterick, R. Stroud, J. Finer-Moore, N.-H. Xuong, R. Hamlin, W. J. Rutter & C.S. Craik.Science 237, 905-909 (1987)

Isolation and Characterization of a cDNA Encoding Rat Cationic Trypsinogen. T. Fletcher, M. Alhadeff, C.S. Craik & C. Largman. Biochem. 26, 3081-3086 (1987)

In Vitro Mutagenesis of Trypsinogen: The Role of the N-Terminus in Intracellular; Protein Targeting to Secretory Granules. T.L. Burgess, C.S. Craik, L. Matsuuchi & R.B. Kelly. J. Cell Bio. 105, 659-668 (1987)

Expression and Overproduction of Proteins. C.S. Craik. In: Protein Structure, Folding and Design 2, pp. 467-476. Edited by D. Oxender. New York: Alan R. Liss, Inc. (1987)

Evolution of Catalysis in the Serine Proteases. J.N. Higaki, B.W. Gibson & C.S. Craik. In: Cold Spring Harbor Symposia on Quantitative Biology 52, pp. 615-621.  New York: Cold Spring Harbor (1987)

1986

Genetic Analysis of Cystic Fibrosis: Linkage of DNA and Classical Markers in Multiplex Families. A. Bowcock, J. Crandall, L. Daneshvar, G. Lee, B. Young, V. Zunzunegui, C.S. Craik, L. Cavalli-Sforza & M-C. King.Am. J. Hum. Genet. 39,699-706 (1986)

Probing the Role of Tyrosine 248 in Carboxypeptidase A with Site-Directed Mutagenesis. S. Gardell, C.S. Craik, D. Hilvert, M. Urdea & W. Rutter. In: Comparative Analysis of Catalytic Mechanisms of Zinc Enzymes. Edited by I. Bertini, C. Luchinat, W. Maret, and M. Zeppezauer. Boston, Massachusetts: Birkhäuser (1986)

1985

Use of Oligonucleotides for Site-Specific Mutagenesis. C.S. Craik. Biotechniques  3,12-19 (1985)

Redesigning Trypsin: Alteration of Substrate Specificity, Catalytic Activity and Protein Conformation. C.S. Craik, C. Largman, T. Fletcher, P. Barr, R.J. Fletterick & W.J. Rutter. Science 228, 291-297 (1985)

Site-Directed Mutagenesis Shows that Tyrosine 248 of Carboxypeptidase A Does Not Play a Crucial Role in Catalysis. S. Gardell, C.S. Craik, D. Hilvert, M. Urdea & W.J. Rutter. Nature 317, 551-555 (1985)

The Exocrine Protein Trypsinogen is Targeted into the Secretory Granules of an Endocrine Cell Line: Studies by Gene Transfer. T.L. Burgess, C.S. Craik & R.B. Kelly. J. Cell Bio. 101, 639-645 (1985)

1984

Structure of Two Related Rat Pancreatic Trypsin Genes. C.S. Craik, Q.-L. Choo, G. Swift, C. Quinto, R. MacDonald & W.J. Rutter. J. Bio. Chem. 259,14255-14264 (1984)

Isolation and Sequence of a Rat Chymotrypsinogen B Gene. G. Bell, C. Quinto, M. Quiroga, P. Valenzuela, C.S. Craik & W.J. Rutter. J. Bio. Chem. 259, 14265-14270 (1984)

Structure of the Two Related Elastase Genes Expressed in the Rat Pancreas. G. Swift, C.S. Craik, J. Stary, C. Quinto, R. Lahaie, W.J. Rutter & R. MacDonald. J. Bio. Chem. 259, 14271-14278 (1984)

Chromosomal Assignment of Genes for Trypsin, Chymotrypsin B, and Elastase in Mouse. N.K. Honey, A.Y. Sakaguchi, P.A. Lalley, C. Quinto, R.J. MacDonald, C. S. Craik, G. Bell, W.J. Rutter & S.L. Naylor. Som. Cell Mol. Gen. 10, 377-383 (1984)

Chromosomal Assignment of Human Genes for Serine Proteases Trypsin, Chymotrypsin B and Elastase. N.K. Honey, A.Y. Sakaguchi, C. Quinto, R.J. MacDonald, G.I. Bell,  C.S. Craik, W.J. Rutter & S.L. Naylor. Som. Cell Mol. Gen. 10, 369-376 (1984)

1983

Splice Junctions: Association with Variation in Protein Structure. C.S. Craik, W.J. Rutter & R.J. Fletterick. Science 220, 1125-1129 (1983)

1982

Oxygen Binding Properties of the Product of the Central Exon of Beta-Globin Gene. C.S. Craik, S.R. Buchman, & S. Beychok. Nature 291, 87-90 (1981)

Intron-Exon Splices Junctions Map at Protein Surfaces. C.S. Craik, S. Sprang, R.J. Fletterick & W.J. Rutter. Nature 299,180-182 (1982)

Concept of a Heme Binding Domain in Relation to Gene Structure. C.S. Craik & S. Beychok. In: Interaction Between Iron Proteins in Oxygen and Electron Transport, pp. 192-197. Edited by C. Ho. New York: Elsevier North Holland Biomedical Press (1982)

The Relationship of Gene Structure to Protein Structure. C.S. Craik, O. Laub, G.I. Bell, Sprang, R.J. Fletterick & W.J. Rutter. In: Gene Regulation, UCLA Symp. Mol. Cell Biol. XXVI, pp. 35-55. Edited by B. O’Malley and C.F. Fox. New York: Academic Press (1982)

1981

Oxygen Binding Properties of the Product of the Central Exon of Beta-Globin Gene. C.S. Craik, S.R. Buchman, & S. Beychok. Nature 291, 87-90 (1981)

1980

Characterization of Globin Domains: Heme Binding to the Central Exon Product. C.S. Craik, S.R. Buchman & S. Beychok. Proc. Natl. Acad. Sci. USA 77,1384-1388 (1980)

Refolding Defects in Hemoglobin Rothschild. C.S. Craik, I. Vallette, S. Beychok & M. Waks. J. Bio. Chem. 255, 6219-6223 (1980)